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Lateral bone-defects were created in rat femoral condyles and tested for the influence of the different implants by measuring the length of lumens at 4 weeks. Titanium implants covered with PCL and functionalized with HMGB1 showed significantly higher values compared to the titanium implants without cytokine supplementation, whereas implants with PCL and functionalized with VEGF did not show any differences.
In conclusion, porous implants functionalized with cytokines are promising materials for bone tissue engineering. The results from the present study demonstrate that titanium implants made of a Ti6Al4V alloy coated with PCL and functionalized with cytokines are suitable for improving tissue regeneration.
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